Declan O'Regan

o regan declan
Professor of Imaging Sciences
MRC Laboratory of Medical Sciences, Imperial College, London

 

Background and Research Interests

 

Declan is British Heart Foundation Chair of Cardiovascular MRI,  MRC Investigator and Consultant Radiologist who leads the Computational Cardiac Imaging Group at the MRC Laboratory of Medical Sciences. He is also Director for Imaging Research at Imperial College Healthcare NHS Trust. He is a past Roentgen (UK) and Rowan-Williams (Australasia) travelling professor lecturing on the role of artificial intelligence (AI) in healthcare. He is past board member for the British Society of Cardiac MR and chairs the Publications Committee of the Society of Cardiac MR.

Declan’s research is focussed on using machine learning to discover mechanisms that underpin common cardiovascular diseases by integrating data from human imaging, genetics and environmental risk factors. His work includes developing algorithms for predicting human survival from cardiac motion and understanding how complex traits influence the risk of heart failure. He also collaborates with industry to accelerate progress in drug discovery using automated genotype-phenotype modelling.

Publications:

  1. Genetic and phenotypic architecture of human myocardial trabeculation. McGurk KA. et al. (2024). Nature Cardiovascular Research. 
  2. Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy. Curran L. et al. (2023). Circulation Genomics and Precision Medicine
  3. Environmental and genetic predictors of human cardiovascular ageing. Shah M. et al. (2023). Nature Communications
  4. Genetic and environmental determinants of diastolic heart function. Thanaj, M. et al. (2022). Nature Cardiovascular Research
  5. Genetic and functional insights into the fractal structure of the heart. Meyer HV. et al. (2020). Nature