Christoph Sandmann

christoph sandmann jpg
Research Fellow in Genetics, Department of Genetics, Harvard Medical School

Christoph is a physician-scientist with a scientific background in cardiac genetics, molecular and cell biology and bioinformatics and is a postdoctoral fellow under the mentorship of Dr. Christine Seidman and Dr. Jonathan Seidman. He has a strong interest in the genetics of cardiac and muscle disease, gene therapy and regeneration. He received his medical degree from the Heidelberg University, Germany, investigating protein homeostasis during cardiac hypertrophy, and completed his PhD at the German Centre for Cardiovascular Research in Heidelberg, Germany where he studied gene expression networks during cardiac remodeling and inflammation. During his clinical training at the Center for Pediatric and Adolescent Medicine, his research focused on genetics of pediatric heart disease. His current work in the Seidman Lab focuses on the investigation of cellular and molecular properties of the pediatric heart and its changes during maturation and disease.

Publications:

1. Clinical characteristics and etiology-specific outcome in pediatric hypertrophic cardiomyopathy Sandmann C. et al (2025) Clinical Research in Cardiology, Spring Nature

2. A cross-species multimodal database of gene expression in cardiac hypertrophy Sandmann C et al (2025) bioRxiv

3. Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response. Hofmann C et al (2022) bioRxiv
4. ATF6 protects against protein misfolding during cardiac hypertrophy  Hofmann C et al (2024) Journal of Molecular and Cellular Cardiology

5. Protein Misfolding in Cardiac Disease. Hofmann C et al (2019) American Heart Association