University of Oxford, Division of Cardiovascular Medicine, Radcliffe Department of Medicine
Background and research interests
My research combines understanding the molecular mechanisms of inherited cardiomyopathies and developing genetic therapies. As a senior postdoctoral researcher on CureHeart, I am developing innovative gene editing tools to correct the genetic variants that cause inherited cardiomyopathies.
I have studied inherited genetic variants in genes that encode for proteins involved in the pathogenesis of hypertrophic (HCM) and dilated (DCM) cardiomyopathy. My work has developed myofilament specific genetically encoded calcium sensors for the study of subcellular calcium dynamics in cardiomyocytes expressing HCM and DCM mutations.
My work utilises human induced pluripotent stem cell (hiPSC) derived cardiomyocytes as a cellular model when investigating inherited cardiomyopathies and testing genetic therapies.