Eric Wei

eric wei
Postdoctoral Researcher
Division of Cardiovascular Medicine, Brigham and Women’s Hospital; Department of Genetics, Harvard Medical School

Background and research interests:

Eric Wei is a clinical cardiology fellow at Brigham and Women’s hospital, and a postdoctoral research fellow in Drs. Christine and Jonathan Seidman’s lab at Harvard Medical School. He obtained his PhD from Duke University under the mentorship of Dr. Geoffrey Pitt. In his graduate work, he discovered a novel role for the non-canonical fibroblast growth factor FGF13 in regulating caveolae and hypertrophic signalling in cardiomyocytes. His current research focuses on mechanisms of cardiac hypertrophy and arrhythmogenesis in genetic heart disease. In the context of hypertrophic cardiomyopathy, his work utilizes advanced microscopy and computational image analyses to better understand how individual cardiac cells remodel in response to pathogenic mutations.

Publications:    

  1. Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. Wei E et al. (2017). Proceedings of the National Academy of Sciences USA.
  2. Fibroblast Growth Factor Homologous Factors Modulate Cardiac Calcium Channels. Hennessey J and Wei E et al. (2013). Circulation Research.
  3. Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Wei E et al. (2012). Trends in cardiovascular medicine.
  4. Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. Wang, C, Tang, H, Wei, E et al. (2017). Journal of Molecular and Cellular Cardiology.
  5. FGF12 is a candidate Brugada syndrome locus. Hennessey J, Marcou C, Wang C, Wei E et al. (2013). Heart rhythm.