Gregory A Newby

Name: Gregory A Newby, PhD
 

Job title: Assistant Professor of Genetic Medicine and Biomedical Engineering, Johns Hopkins University School of Medicine

Background and research interests:

Greg conducted his PhD work with Susan Lindquist at MIT developing tools to study protein aggregation. He was then a postdoctoral fellow in the lab of David Liu at Harvard University and the Broad Institute from 2017-2023 where he adapted base editing and prime editing tools to treat models of genetic disease. Greg developed editing tools that yielded 80% in vivo correction of the hypertrophic cardiomyopathy mutation MYH7 R403Q in left ventricular cardiomyocytes in a mouse model, preventing hypertrophy.

As of 2023, Greg has been leading his own research group at Johns Hopkins University focused on advancing these tools to be generalizable to HCM mutations. He is supported by the K99/R00 Pathway to Independence award from the NHLBI, a Pioneer award from the Cystic Fibrosis Foundation, and funding from the Solve GNE Foundation.

Publications:    

1. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Reichart D and Newby GA et al. (2023). Nature Medicine 
2. Base editing of hematopoietic stem cells rescues sickle cell disease in mice. Newby GA, Yen JS, Woodard KJ and Mayuranathan T et al. (2021). Nature  
3. Potent and uniform fetal hemoglobin induction via base editing. Mayuranathan T and Newby GA et al. (2023). Nature Genetics
4. In vivo somatic cell base editing and prime editing. Newby GA and Liu DR. (2021). Molecular Therapy 
5. A genetic tool to track protein aggregates and control prion inheritance Newby GA, Kiriakov S and Hallacli et al. (2017) Cell.