Wei-Wen Lim

Wei-Wen completed his PhD at University of Adelaide under the supervision of Professors David Saint and Prash Sanders, studying cardiac remodelling and arrhythmias in preclinical models of hypertrophic cardiomyopathy and diabesity. He begun his postdoctoral work with Professor Stuart Cook at the National Heart Centre Singapore as a Research Fellow in 2016, jointly appointed by the Programme in Cardiovascular & Metabolic Disorders at Duke-NUS Medical School. In his work, he established the pro-fibrotic and pro-inflammatory roles by interleukin-11 in the cardiovascular system.

Wei-Wen has keen interests in identifying novel factors in cardiac arrhythmias, cardiomyopathies, and vasculopathies. The team does this by utilizing preclinical models to study disease mechanisms, employing cell and molecular biology techniques with applied physiology, with the aim of developing new therapeutics for cardiovascular disorders.  

Publications:    

1. IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome. Ng B et al. (2023). Arteriosclerosis, Thrombosis and Vascular Biology
2. Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome. Lim WW et al. (2022).  Circulation Research
3. Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation. Lim WW et al. (2021). International  Journal of Molecular Sciences
4. Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models. Lim WW and Corden B et al. (2020). Scientific Reports